OMAHA, Neb. (AP) - Kyle O'Quinn had 26 points and 14 rebounds, making several key plays in the closing minutes, and Norfolk State held on to stun Missouri.
Pendarvis Williams and Chris McEachin each added 20 points for the MEAC champion Spartans (26-9), who made their first trip to the NCAA tournament a memorable one. They became the first No. 15 seed to beat a No. 2 since fellow conference member Hampton knocked off Iowa State in 2001.
O'Quinn had a chance to take some of the drama out of the finish when he went to the free throw line with 3.8 seconds to go, but the 70-percent foul shooter missed both tries.
Missouri coach Frank Haith called a timeout with 2.9 seconds left to set up a final play, and the ball wound up in the hands of Phil Pressey. He took a couple of hard dribbles and let loose a 3-pointer from the wing that clanked off the back iron as the buzzer sounded.
XAVIER 67
NOTRE DAME 63
GREENSBORO, N.C. (AP) - Tu Holloway banked in the go-ahead shot over Jack Cooley with 21.3 seconds left, helping Xavier rally for the win.
Holloway finished with 25 points on 10-for-15 shooting, including a flurry that helped the 10th-seeded Musketeers (22-12) rally from a 10-point second-half deficit against the seventh-seeded Fighting Irish (22-12). His final points came when he rounded a screen from Kenny Frease and sent a high-arcing shot over Cooley's outstretched arm for the 64-63 lead.
Dezmine Wells finished with 14 points and 11 rebounds for Xavier, which will play No. 15 seed Lehigh in Sunday's third round.
FLORIDA 71
VIRGINIA 45
OMAHA, Neb. (AP) - Bradley Beal had 14 points and 11 rebounds, reserve Casey Prather scored a career-high 14 and Florida pulled away in the second half to beat Virginia.
The Gators (24-10) finished the first half on a 17-4 run to shake off a slow start and get out to a 30-22 lead. They shot 70 percent in the second half, pushing their lead to more than 20 points.
MICHIGAN STATE 89
LIU BROOKLYN 67
COLUMBUS, Ohio (AP) - Draymond Green scored 24 points in a triple-double and top-seeded Michigan State fought off the upset bug that took down two No. 2 seeds in the NCAA tournament.
The Spartans (28-7) finally put away the pesky No. 16 Blackbirds (25-9) with a 14-4 run midway through the second half.
SAINT LOUIS 61
MEMPHIS 54
COLUMBUS, Ohio (AP) - Kwamain Mitchell scored 22 points, including three big 3-pointers, and Saint Louis rode its gritty defense to a victory over Memphis.
Mitchell closed the first half by banking in a 3, then nailed two others to help coach Rick Majerus and the Billikens (26-7) overturn an eight-point deficit in the second half. They moved on to play the winner of LIU Brooklyn and top-seeded Michigan State on Sunday.
FLORIDA STATE 66
ST. BONAVENTURE 63
NASHVILLE, Tenn. (AP) - Bernard James scored 19 points and Florida State barely avoided a big upset, rallying to beat St. Bonaventure.
Andrew Nicholson scored 20 points and Demetrius Conger had 14 for St. Bonaventure (20-12), which was trying to win an NCAA tournament game for the first time since 1970.
CINCINNATI 65
TEXAS 59
NASHVILLE, Tenn. (AP) - Yancy Gates had 15 points and 10 rebounds as Cincinnati started strong and then withstood a late rally by Texas.
The Bearcats (25-10) jumped out to a 16-2 lead while Texas opened the game 1 of 14 from the field and shot 16 percent for the first half. After trailing 31-17 at halftime, the Longhorns attacked, hitting five of their first seven from 3-point range.
NORTH CAROLINA 77
VERMONT 58
GREENSBORO, N.C. (AP) - Tyler Zeller had 17 points and 15 rebounds to help North Carolina beat Vermont in its NCAA tournament opener despite playing without injured starter John Henson.
Freshman forward James Michael McAdoo added a season-high 17 points for the Tar Heels (30-5), who pushed ahead by double figures late in the first half and then broke the game open after halftime. They improved to 30-1 in NCAA tournament games played in their home state.
CREIGHTON 58
ALABAMA 57
GREENSBORO, N.C. (AP) - Doug McDermott scored 16 points and Creighton overcame an 11-point deficit in the second half to beat Alabama for its first NCAA tournament victory in 10 years.
Alabama had a chance to win during the frantic final seconds, but Josh Jones blocked Trevor Releford's 3-point attempt from the top of the key as time expired.
OHIO 65
MICHIGAN 60
NASHVILLE, Tenn. (AP) - D.J. Cooper scored 21 points and Ohio held off Michigan for yet another second-round upset in the NCAA tournament.
The underdog Bobcats (28-7) had the Wolverines on their heels throughout the game, but Trey Burke hit a 3-pointer with 4:12 left to cut it to 63-60. Michigan then missed its final five shots, four by Burke.
FLORIDA 58
TEMPLE 44
NASHVILLE, Tenn. (AP) - Victor Rudd Jr. and Anthony Collins each scored 17 points, and South Florida shook off a frigid first 20 minutes to earn the upset.
The 12th-seeded Bulls (22-13) took it to the Atlantic 10 regular-season champ with their bruising Big East-style of play and held Temple 20 points below its previous season low in scoring.
GEORGETOWN 74
14 BELMONT 59
COLUMBUS, Ohio (AP) - Jason Clark scored 21 points, Otto Porter added 16 and Georgetown's ruthless defense bottled up Belmont's shooters, sending the Hoyas into the next round of the NCAA tournament after early exits the past two years.
Henry Sims had 15 points for the Hoyas (24-8), who shot 62 percent from the floor and will play No. 11 seed North Carolina State in the third round Sunday.
Blake Jenkins scored 17 to lead Belmont, which went just 10 of 27 on 3-pointers.
NC STATE 79
SAN DIEGO STATE 65
COLUMBUS, Ohio (AP) - Richard Howell scored 22 points, double his season average, and North Carolina State used its muscle inside and sticky defense to beat San Diego State.
Lorenzo Brown added 17 points and C.J. Leslie 15 for the Wolfpack (23-12), who improved to 12-5 in NCAA tournament openers. N.C. State has won at least one game in seven of its last eight trips.
KANSAS 65
DETROIT 50
OMAHA, Neb. (AP) - Thomas Robinson had 16 points and 13 rebounds, and second-seeded Kansas rolled to the victory.
Elijah Johnson added 15 points and Tyshawn Taylor had 10 for the Jayhawks (28-6), who toyed with the Titans (22-14) for the first 15 minutes before ramping up the defense.
PURDUE 72
SAINT MARY'S 69
OMAHA, Neb. (AP) - Lewis Jackson made the go-ahead free throws for Purdue with 22.8 seconds left after Saint Mary's had rallied late from 11 points down to take its first lead.